Carbonic anhydrase



Carbonic anhydrase (CA) are enzymes which catalyze the interconversion of CO2 and water to bicarbonate and proton. The active site contains Zn atom. For full entry on γ-carbonic anhydrase see Gamma Carbonic Anhydrase

3D Structures of Carbonic anhydrase
Update June 2011

α-carbonic anhydrase
Carbonic anhydrase I

1crm, 2cab – hCA1 - human

1jv0 – hCA1 (mutant)

1j9w - hCA1 (mutant) – NMR

3lxe, 2it4, 2nn7, 2nmx, 2nn1, 1azm, 1bzm, 1czm, 1hug, 1huh – hCA1 + inhibitor

1hcb – hCA1 + bicarbonate

2fw4 – hCA1 + activator

Carbonic anhydrase II

1v9e – bCA2 – bovine

1v9i – bCA2 ( mutant)

3mwo, 3ks3, 3gz0, 3efi, 2ili, 2ax2, 1xev, 1t9n, 1tb0, 1tbt, 1te3, 1teq, 1teu, 1tg3, 1tg9, 1th9, 1thk, 1lug, 1luq, 1cng, 1cnh, 1cni, 1cnj, 1cnk, 1yda, 1ydb, 1ydc, 1ydd, 1ccs, 1cct, 1ccu, 1cvh, 1cvd, 1cve, 1cvf, 1cnb, 1cnc, 4cac, 5cac, 1cva, 1cvb, 1mua, 2cba, 2cbb, 2cbe, 1dca, 1dcb, 4ca2, 5ca2, 12ca, 1ca3, 1hca, 1hea, 1heb, 1hec, 1hed, 6ca2, 7ca2, 8ca2, 9ca2, 1ca2, 2fmg – hCA2

3kkx – hCA2 - Neutron

3koi, 3kok, 3kon, 1rza, 1rzb – hCA2 (Co)

1rzc – hCA2 (Cu)

1rzd – hCA2 (Mn)

1rze – hCA2 (Ni)

1yo0, 1yo1, 1yo2, 1lzv, 1moo, 1fql, 1fqm, 1fqn, 1fr7, 1fsn, 1g3z, 1g0f, 1h9n, 1h9q, 1ugc, 1uge, 1ugf, 1uga, 1ugb, 1ugd, 1ugg, 1zsa, 1zsc, 1cvc, 1cai, 1caj, 1cak, 1cal, 1cam, 1hva, 2fnn, 2wd2, 3m1q, 3m1w, 3m5s, 3m5t  – hCA2 (mutant)

1fqr, 1fsq – hCA2 (Co) (mutant)

1fr4, 1fsr – hCA2 (Cu) (mutant)

1xeg, 1cay, 1caz – hCA2 + acetate

3mnh, 3mni, 3mnj, 3mnk, 3dv7, 3dvb, 3dvc, 3dvd, 2nwo, 2nwp, 2nwy, 2nwz, 2nxr, 2nxs, 2nxt, 2fnk, 2fnm, [[2fnn – hCA2 (mutant)

3ml2, 3mmf, 3mna, 3nb5, 3p4v, 3po6, 3n0n, 3mzc, 3n2p, 3n3j, 3n4b, 3m98, 3m2n, 3m96, 3myq, 3l14, 3kig, 3m1k, 3m67, 3m3x, 3m40, 3m5e, 3mhi, 3mhl, 3mhm, 3mho, 3iqk, 3mhc, 3kwa, 3mnu, 3k34, 2x7s, 2x7t, 2x7u, 3igp, 3hlj, 2wd3, 3ieo, 3hs4, 3k2f, 2weg, 2weh, 2wej, 2weo, 3hkn, 3hkq, 3hkt, 3hku, 3f8e, 3ibi, 3ibl, 3ibn, 3ibu, 3eft, 3ffp, 3f4x, 3d8w, 3d9z, 3daz, 3dbu, 3dc3, 3dc9, 3dcc, 3dcs, 3dcw, 3dd0, 3c7p, 3bet, 3bl1, 2osf, 3cyu, 3caj, 2osm, 2qo8, 2qoa, 3b4f, 3bl0, 2pou, 2pov, 2pow, 2hl4, 2o4z, 2nng, 2nno, 2nns, 2nnv, 2h15, 2gd8, 2hnc, 2f14, 2hoc, 2hd6, 2eu2, 2eu3, 2aw1, 2geh, 1z9y, 1zfk, 1zfq, 1zge, 1zgf, 1zh9, 1ze8, 1xpz, 1xq0, 1ttm, 1oq5, 1kwq, 1kwr, 1if4, 1if5, 1if6, 1if7, 1if8, 1if9, 1i8z, 1i90, 1i91, 1g1d, 1g52, 1g53, 1g54, 1bnq, 1bnt, 1bnu, 1bnw, 1bn1, 1bn3, 1bn4, 1bnm, 1bnn, 1a42, 1bnv, 1am6, 1h4n, 2h4n, 1okl, 1okm, 1okn, 1cnw, 1cnx, 1cny, 1cil, 1cim, 1cin, 1cra, 1bcd, 2ca2, 3ca2, 3m04, 3m14, 3m2x, 3m2y, 3r16, 3r17 – hCA2 + inhibitor

2fos, 2fou, 2fov, 2foy, 2foq - hCA2 + two-prong inhibitor

3kne, 1lg5, 1lg6, 1i9l, 1i9m, 1i9n, 1i9o, 1i9p, 1i9q, 1g45, 1g46, 1g48, 1g4j, 1g4o, 1g0e - hCA2 (mutant) + inhibitor

1cah - hCA2 (Co) + bicarbonate

1lgd, 1bic - hCA2 (mutant) + bicarbonate

3m1j – hCA2 + anticancer metallodrug

3dd8, 2qp6 - hCA2 + anticancer sulfamate

1eou - hCA2 + anticonvulsant sulfamate

2q1q – hCA2 + antiepileptic drug

1zsb – hCA2 + transition state analog

3hfp, 2hkk, 2ez7, 1fmg, 2fmz, 2abe, 1avn – hCA2 + activator

2vva, 3d92, 3d93 – hCA2 + CO2

2vvb – hCA2 + bicarbonate

1f2w – hCA2 + cyanamide

1bv3 – hCA2 + urea

3k7k, 1can, 1cao, 1ray, 1raz, 2cbc, 2cbd – hCA2 + anion

2q38, 2q1b – hCA2 + saccharin

1g6v – bCA2 + antibody heavy chain

Carbonic anhydrase III

2hfw, 2hfx, 2hfy, 1z93, 1z97 – hCA3

1flj – CA3 + inhibitor – rat

Carbonic anhydrase IV

1znc – hCA4

2znc – mCA4 – mouse

3znc – mCA4 + inhibitor

3fw3, 3f7b, 3f7u – hCA4 soluble domain + inhibitor

Carbonic anhydrase V

1urt, 1dmx – mCA5

1dmy – mCA5 + transition state analog

1keq – mCA5 (mutant) + inhibitor

Carbonic anhydrase VI

3fe4 – hCA6

Carbonic anhydrase VII

3mdz – hCA7

3ml5 – hCA7 (mutant)

Carbonic anhydrase VIII

3d0n – hCA8

3czv – hCA8 + inhibitor

Carbonic anhydrase IX

3iai – hCA9 catalytic domain (mutant)

2hkf – hCA9 peptide + antibody

Carbonic anhydrase XII

1jcz - hCA12 extracellular domain

1jd0 - hCA12 extracellular domain + inhibitor

Carbonic anhydrase XIII

3da2 - hCA13 + inhibitor

Carbonic anhydrase XIV

1rj5 – mCA14 extracellular domain

1rj6 – mCA14 extracellular domain + inhibitor

3q31 – CA – Aspergillus oryzae

2w3n, 2w3q – CA2 – Cryptococcus neoformans

1y7w – CA – Dunaliella salina

β-carbonic anhydrase
1qy1, 3qy1 – CA – Salmonella enterica

3eyx – CA residues 14-221 – yeast

2esf, 1t75, 1i6o, 1i6p – CA2 – Escherichia coli

2fgy – CA (mutant) – Halothiobacillus neapolitanus

2a5v, 1ym3 – CA – Mycobacterium tuberculosis

1g5c – CA – Methanobacterkium thermoautotrophicum

1ekj – CA – pea

1ddz – CA – Porphyridium purpureum

3mf3 – HiCA (Co) – Haemophilus influenza

2a8c - HiCA

3e2w, 3e2x, 3e31, 3e3f, 3e3g, 3e3i, 3e1v, 3e1w, 3e24, 3e28, 3e2a – HiCA (mutant)

2a8d – HiCA + bicarbonate

γ-carbonic anhydrase
1qre, 1qrf, 1qrg, 1qrl, 1qrm, 1thj – MtCA – Methanosarcina thermophila

1qq0 – MtCA (Co)

2fko – PhCA – Pyrococcus horikoshii

1v67, 1v3w - PhCA + bicarbonate

3r1w – CA – unidentified

3bob, 3boe, 3boh – TwCA (Cd) domain 2 – Thalassiosira weissflogii

3boj - TwCA domain 1

3boc - TwCA domain 2

1kop, 1koq – CA – Neisseria gonorrheae